C1-Esterase Inhibitor: Biological Activities and Therapeutic Applications
نویسندگان
چکیده
منابع مشابه
C1-Esterase Inhibitor: Biological Activities and Therapeutic Applications
Human C1-esterase inhibitor (C1-INH) is a unique anti-inflammatory multifunctional plasma protein best known for its key role in regulation of the classical complement pathway, contact activation system and intrinsic pathway of coagulation. By sequence homology and mechanism of protease inhibition it belongs to the serine proteinase inhibitor (serpin) superfamily. However, in addition to its in...
متن کاملCLINICAL REVIEW Acquired C1 Esterase Inhibitor Deficiency
Acquired C1 esterase inhibitor deficiency is a rare condition associated with autoimmune or low-grade lymphoproliferative disorders. Adults or elderly patients are most commonly affected. The diagnosis is suspected when patients present with recurrent angioedema and low serum levels of C4 with normal levels of C3. Low levels of C1q and low C1 esterase inhibitor activity confirm the diagnosis. I...
متن کاملangioedema in a patient with c1 esterase inhibitor deficiency
angioedema is characterized by recurrent, circumscribed, solitary or multiple subcutaneous and mucosal swelling, involving the extremities, face, larynx, bowel wall. angioedema is due to hereditary or acquired varieties of c1 esterase inhibitor (c1inh) deficiency. a case of atypical acquired angioedema in a 49-year old man, responding favourably to cinnarizine and alcohol abstinence, is present...
متن کاملC1 esterase inhibitor deficiency, airway compromise, and anesthesia.
H ereditary angioedema (HAE) is a serious genetic abnormality involving the complement system and characterized by episodic and sometimes life-threatening airway edema. In 1882, von Quincke (1) published the first detailed description, and 3 yr later, Strubing used the term angioedema to describe this disorder. By 1888, Osler (2) had demonstrated the hereditary nature of the clinical presentati...
متن کاملTherapeutic application of C1 esterase inhibitor concentrate for clinical amniotic fluid embolism: a case report
We present the successful application of C1 esterase inhibitor (C1INH) concentrate to a patient with clinical amniotic fluid embolism (AFE).
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ژورنال
عنوان ژورنال: Journal of Hematology & Thromboembolic Diseases
سال: 2013
ISSN: 2329-8790
DOI: 10.4172/2329-8790.1000113